PPAR Pathway
Weight gain and genetics – How to know your genetics can help with weight control
Obesity is very common disease influenced by the interaction of multiple factors such as environment, genetics and dietary factors. Obese Everyone aims to reduce the weight by using different management approaches such as diet, exercise and diet pills. But knowledge about the relationship between genetics and obesity facilitates the process of weight control. Here is a discussion on the different genes that play a role in the development of obesity.
genetic approach to understanding obesity
Information gene encoded by the DNA (deoxyribonucleic acid) determines the physiological functions living organisms. A small piece of DNA that encodes a particular protein is known as the gene. A single nucleotide change in the sequence of the gene that increases susceptibility or resistance to a particular disease. However, obesity is not caused by variations in a single gene, but rather by a polygenic effect due to interaction several genes. Alteration of the genes responsible for increased susceptibility to disease (obesity in this case) are called susceptibility genes. These genes work in association with environmental factors such as diet, smoking and physical activity. Children of obese susceptibility genes are at high risk of developing obesity. This is due to the inheritance of susceptibility genes of children from parents.
susceptibility genes responsible for obesity
Obesity is directly or indirectly linked to about 425 genes. These genes have effects on the control of energy metabolism, the measurement of food intake tract metabolic and signaling and synthesis of fats. These in turn regulate the level of body fat stores and weight as well.
The genes that regulate energy metabolism: ADRβ2, ADRβ3, PPAR, FABP etc.
The genes that regulate the extent of food intake: NPY, CCK, POMC, maternal health and child, etc.
The genes that regulate metabolic and signaling pathways: PPAR, FABP, PKA, C / EBP, etc.
All above genes, variations in the genes coding for β-adrenergic receptors and RPLS are primarily responsible for obesity.
Using information genetics for weight control
effective weight management is possible by knowing the genetic DNA. For example, some common ways to lower weight consumed diets low in carbohydrates, low fat diet and increased physical activity. You may be confused which one to choose.
While the subject of a href = "http://www.testcountry.com/categories.html?cat=398"> Genetic test. If the results indicate that genes regulating the synthesis of modified receptors beta-adrenergic, then you must make an effort to burn more energy. Wondering why? Here is a simple explanation.
Receivers beta adrenergic receptors are present in the cell membranes of many cells. Suitable substrate binding, mobilize stored energy. This energy expenditure made in the form of fat breakdown and heat production in brown adipose tissue. Therefore, any modification of the genes encoding these receptors hinders the process of mobilization of energy. This increases the risk of gaining weight. Therefore, people with defective genes ADRβ2 ADRβ3 should undergo routine physical activity to prevent weight gain.
About the Author
This Article is written by Lena Butler, the author of TestCountry Articles a longer version of this article is located at Gaining Weight and Genetics – How Knowing Your Genetics Can Help You with Weight Management, and resources from other home health and wellness testing articles are used such as Genetic Testing.
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